I deployed a Cisco UCS B200 server with a VIC 1380 and created a service profile from a template I always use. I assigned the service profile to the server and installed ESXi. I noticed the server was having network connectivity problems. It was intermittently dropping packets on a continuous ping.

I narrowed down that the issue was only occurring on a NIC going though Fabric Interconnect A. The network connectivity was fine on Fabric Interconnect B. No other servers were having the issue. I did more troubleshooting at that point with Cisco TAC.

Turns out the service profile was the issue. I unassigned the service profile, created a new profile from the same template, and assigned it to the server. Then network connectivity was working fine.